Of the participants 18—74 y , higher urinary BPA concentrations were associated with an increased prevalence of diabetes OR 1.
Microenvironmental regulation of tumour angiogenesis
The study results implicated high serum BPA concentrations with the presence of antinuclear antibodies, but not with hypothyroidism, hyperprolactinaemia, luteal phase defects, natural killer cell activity, or antiphospholipid antibodies, suggesting that BPA exposure might be associated with recurrent miscarriages.
However, the causal relationship between BPA and miscarriages was not conclusive because other probable risk factors for miscarriage were not included for a comprehensive analysis. An examination of the Danish Occupational Hospitalization Register between and revealed that increased incidence of infertility was observed among women working in the plastics industry Hougaard and others This study showed that, among female plastic workers, cases of treatment for female infertility were observed compared to an expected For male workers, the numbers were 41 and These data suggest that exposure to chemicals generated from the plastics industry may be weakly associated with female infertility, but not with male infertility.
Danish children are exposed simultaneously to multiple phthalates. Numerous plastic ingredients have been used for the manufacture of consumer products and human safety concerns regarding their use in plastic food containers have been raised. Although the use of synthetic resins may differ from country to country, the major synthetic resins used for plastic containers in Korea are: PE EPA U. Volume 11 , Issue 5. The full text of this article hosted at iucr.
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JCI - Tumor endothelial marker 1–specific DNA vaccination targets tumor vasculature
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DEHP 37 4. Compound Study population Study method Results Ref. Chromosomal aberrations and micronuclei in reinforced plastics workers exposed to styrene. Mut Res 1—2 : 41 — 7. Google Scholar. CAS Google Scholar. PubMed Google Scholar. Crossref Google Scholar. Citing Literature. Volume 11 , Issue 5 September Pages Figures References Related Information. Close Figure Viewer. Browse All Figures Return to Figure. Previous Figure Next Figure.
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Lee and Koo IARC Galloway and others Zeiger and others Valencia and others Wolfe and Layton Ema and others Piersma and others Kwack and others Kim and others New Forests. Patterns of genetic variation in Cordia africana , a tropical timber species, were evaluated at the population level. Bulk seed samples were collected from six natural populations in Ethiopia and examined for variations in seed morphometric traits, seed germination, and seedling growth at nursery stage.
Seed weight showed a significant positive correlation with altitude and negative correlation with mean annual temperature of seed origin. Germination energy was significantly correlated with longitude and mean annual rainfall. Seedling parameters and geo-climatic variables of seed origin were fairly correlated. It can be concluded that the observed patterns of variation will have implications for genetic resources conservation and tree improvement. Unable to display preview. Download preview PDF. Skip to main content.
Original Research ARTICLE
Advertisement Hide. This is a preview of subscription content, log in to check access. Using pcDNA3. This fusion construct was used to vaccinate healthy mice at 1-week intervals for a total of 3 immunizations. Splenocytes harvested from vaccinated mice were stimulated with a TEM1 peptide library consisting of 15 mers that overlap by 10 aa. The TEM1 library encompassing the entire protein sequence was divided into 4 pools: pool A sequences spanning aa 1— , pool B aa — , pool C aa — , and pool D aa — Characterization of TEM1 immunodominant epitopes.
Peptides from pool C C or pool D D were divided into 7 minipools of 15 mers, so each individual peptide was present in 2 minipools and could be identified through an experimental matrix design.
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C Reactivity to pool C was present in minipools f , g , and 5. D Reactivity to pool D was present in minipools a and 6. Data are from 1 of 3 independent experiments. TEM1-specific reactivity was found against minipools f , g , and 5 Figure 2 C. MBL2 leukemia cells were used as the stimulatory cells. Mice were vaccinated 3 times i.
These results reinforced the notion that the fusion construct Tem1-TT vaccine is essential to break TEM1 tolerance and generate protective immunity. Tem1-TT vaccination controls tumor progression. A Tumor control in a prophylactic setting. Tem1 and Tem1-TT vs. TT compared with the single constructs and saline control Figure 3 , B and C. Cumulatively, these data indicate that the Tem1-TT vaccine induces significant T cell infiltration within tumors and exerts potent antitumor activity. In simultaneous experiments, the serum from immunized mice was also transferred to naive mice.
Mice were then sublethally irradiated and challenged with TC1 tumor. Therefore, although antibodies may be generated by the Tem1-TT vaccine, the results of our adoptive transfer experiments ruled out any humoral contribution to antitumor efficacy. Tem1-TT vaccination inhibits tumor vascularization.